Table 1. Serological parameters of MC4R-KO and WT mice treated with EPA for 24 weeks.
| WT | MC4R-KO | ||
|---|---|---|---|
| SD | Control | EPA-pre | |
| BG (ad lib, mg/dL) | 144.0 ± 7.3 | 134.3 ± 9.7 | 119.1 ± 6.2 |
| Insulin (ad lib, ng/mL) | 0.6 ± 0.1 | 4.3 ± 1.3** | 3.7 ± 1.8 |
| TG (mg/dL) | 57.1 ± 30.9 | 30.9 ± 3.2** | 34.6 ± 6.0 |
| TC (mg/dL) | 70.8 ± 3.0 | 290.1 ± 15.0** | 122.5 ± 8.3 ¶ |
| FFA (mEq/L) | 1.13 ± 0.10 | 1.33 ± 0.09 | 0.80 ± 0.05 ¶ |
| ALT (IU/L) | 47.5 ± 5.6 | 539.1 ± 87.2** | 120.5 ± 16.8 ¶ |
| Adiponectin (μg/mL) | 12.7 ± 1.4 | 7.8 ± 1.0 | 17.7 ± 2.0 ¶ |
| Leptin (ng/mL) | 8.7 ± 1.8 | 114.3 ± 4.5** | 119.9 ± 8.9 |
WT, wildtype; SD, standard diet; BG, blood glucose; TG, triglyceride; FFA, free fatty acid; TC, total cholesterol; ALT, alanine aminotransferase. Data are expressed as the mean ± SE.
**P < 0.01 vs. WT-SD
¶ P < 0.01 vs. MC4R-Control. n = 7–10