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Changes in LFTs with TDM-1 treatment. Serum bilirubin (μmol/l), alanine transaminase (U/l) and alkaline phosphatase (U/l) levels are shown. The normal ranges (NR) for bilirubin, alanine transaminase and alkaline phosphatase are <17 µmol/l, <40 U/l and 24–110 U/l, respectively. Each cycle of TDM-1 treatment is shown along with its cycle number, dose and any dose reduction instituted. Day 0 represents the administration of the first cycle of TDM-1.
