Table 6.

Distribution-based and anchor-based estimates of important differences

		Fatigue/activity		Appetite/eating
1/3 SD	Baseline	1.2		1.3
	Week 3	1.3		1.3
	Week 6	1.3		1.2
	Week 9	1.3		1.2
	Week 12	1.3		1.2
1/2 SD	Baseline	1.8		1.9
	Week 3	2.0		1.9
	Week 6	1.9		1.8
	Week 9	1.9		1.8
	Week 12	1.9		1.8
SEM	Baseline	1.5		2.0
	Week 3	1.6		2.0
	Week 6	1.5		1.9
	Week 9	1.5		1.8
	Week 12	1.4		1.8
Cross-sectional anchors	Baseline–My friends and family are pleased with my appetite	Not at all vs a little bit	1.42	A little bit vs somewhat	2.15
		A little bit vs somewhat	1.35	Somewhat vs quite a bit	1.97
		Somewhat vs quite a bit	1.20	Quite a bit vs very much	2.22
	Week 6–Performance status	<70 vs 70–80	1.61	<70 vs 70–80	1.42
		70–80 vs 90–100	1.42	70–80 vs 90–100	1.55
	Week 6–My friends and family are pleased with my appetite	A little bit vs somewhat	1.85	Not at all vs a little bit	1.16
		Somewhat vs quite a bit	1.73	Quite a bit vs very much	1.06
	Week 12–Performance status	<70 vs 70–80	1.88
		70–80 vs 90–100	1.92
	Week 12–I have felt hungry			A little bit vs somewhat	1.94
				Somewhat vs quite a bit	0.85
	Week 12–My friends and family are pleased with my appetite	Not at all vs a little bit	1.24	Not at all vs a little bit	2.13
		A little bit vs somewhat	2.43	Somewhat vs quite a bit	1.14
		Somewhat vs quite a bit	0.81
		Quite a bit vs very much	1.48
Longitudinal anchors	Week 6–Change in body weight			Decreased 3 kg or more	0.69
				Increased 1–2.99 kg	1.47
	Week 9–Change in body weight			Decreased 3 kg or more	2.33
				Increased 1–2.99 kg	1.35
	Week 12–Change in body weight			Decreased 3 kg or more	2.27
				Increased 1–2.99 kg	1.21
Median (IQR)		1.5 (1.3–1.9)		1.8 (1.2–2.0)

For anchor-based analyses, only group comparisons that met all three criteria are presented: (1) correlation ≥0.3, (2) group n ≥ 10, and (3) effect size between 0.2 and 0.8

IQR interquartile range