Table 3.
IPA analysis of signaling pathways involved in cell-death and cell-to-cell signaling events
| Category | Subtype | Compartment | Hubs | DEGs |
|---|---|---|---|---|
| Cell Death | ATC | M, C, N | MMP1+, MMP3+, JNK-, FOXO1-, CASP3+, CASP7+ | MMP1+, NUSAP1+, DEPDC1+, SPINT2- |
| FTC | M | BCR*, NFKB*, ADRB2- | FOSB-, CCL2-, LPL+ | |
| C | IL12*, IFA*, CD3*, CD44+, BAX+, HSP70*, JUN- | JUN-, CD44+ | ||
| N | CTNNB1*, KCNIP4-, PGR* | GDF15+, KLF4-, SLIT2- | ||
| N | AKT*, E2F1*, TP73*, E2F* | SFRP2-, GATA5+ | ||
| PTC | M, C | CG*, FSH*,LH* | PPARGC1A-, SLC4A4-, HMGA2+ | |
| M, C | PI3K family*, AKT*,BCR*, IGs* | PROM1-, IGSF1+ | ||
| C | TGM2+, Caspases* | TIMP1+, SLC25A15, FHL1- | ||
| N | CD44+, AKT1*, GLI1*, POU5F1* | PAPSS2- | ||
| Cell-Cell Signaling | ATC | M | CG*, Secretase gamma*, PLAU+ | PLAU+, PLAUR+, SPP1+, LRP1B-,PPAP2B-, SLC4A4- |
| E | IL1B+, CCL20+, IL1RN+ | TSHR-, PDE8B-, FCGR2A+, TNFA1B6+, TG- | ||
| M | IFNA*, IFNB*, IL12*, MYD88+ | CXCL5+, CD86+, CLEC7A+ | ||
| M | IL8+, CD14+, TLR2+ | IL8+, CCL21-, TLR2+ | ||
| FTC | E, M, C | IL8*, IL13*, COL18A1*, HB*, CBL* | ZMAT3+, GJB6-, EPHB1-,EPHA3- | |
| M | Estrogen receptor*, ITGB1*, CD46*, SPDEF*,FOXA1* | COL13A1+, CDH16- | ||
| M | { } | XPR1+ | ||
| PTC | M, C | NFKB*, GH* | CITED2-,GHR-, CDH3+ | |
| M, C | MAPK1*, F2*, HSF1* | FN1+, SHANK2- | ||
| E | IFNG*, IL1A*, p73* | SERPINA1+, CLMN- |
It is shown the compartment in which the found molecules are more abundant (M for plasma membrane; C for cytoplasm; N for nucleus and E for Extracellular Matrix), The most connected molecules (hubs) and the most differentially expressed genes. The sign (+,- and *) represent overexpression, underexpression and no-change with respect to control.