Table 4.
Validation of top differentially expressed genes in PTC, FTC and ATC with two independent datasets
| Subtype | Gene name | Set 1-Validated | Set 2-Validated |
|---|---|---|---|
| FTC ⇑ | ZCCHC12 | yes | yes |
| PRR15 | yes | yes | |
| CA12 | yes | yes | |
| TENM1 | yes | no | |
| ARHGAP36 | no | no | |
| FTC ⇓ | ADH1B | yes | yes |
| DCN | yes | yes | |
| CCL21 | yes | yes | |
| CHRDL1 | yes | yes | |
| DPT | yes | yes | |
| PTC ⇑ | GABRB2 | yes | yes |
| HMGA2 | yes | yes | |
| PRR15 | yes | yes | |
| CHI3L1 | yes | yes | |
| ZCCHC12 | yes | yes | |
| PTC ⇓ | PKHD1L1 | yes | yes |
| TFF3 | yes | yes | |
| TPO | yes | yes | |
| DIO1 | yes | yes | |
| ADH1B1 | yes | yes | |
| ATC ⇑ | POSTN | yes | yes |
| MMP1 | yes | yes | |
| SPP1 | yes | yes | |
| TFPI2 | yes | yes | |
| VCAN | yes | yes | |
| ATC ⇓ | DIO1 | yes | yes |
| TSHR | yes | yes | |
| TG | yes | yes | |
| SLC26A7 | yes | yes | |
| TPO | yes | yes |
For this analyisis the 5 top overexpressed and underexpressed genes of our datasets was tested against two independent genome-wide gene expression databases (available in Additional file 4). The first column shows over/under-expression of each gene within our set; second column shows the gene names. Gene validation status (cols. 3 and 4) shows that 27 out of 30 relationships were consistent with our original analysis.