Table 6.

Validation of the status of the inhibition of matrix metalloproteinases pathway in PTC and ATC with other sample subset

Subtype	Dataset 1	Dataset 2	Dataset 3
	(original)	(validation 1)	(validation 2)
FTC	Not significant	Not significant	Not significant
PTC	Not significant	Not significant	Not significant
ATC	Active	Not significant	Active

For this IPA/IKB analyisis, the Inhibition of Matrix Metalloproteinases (IMMPP) pathway was tested against two independent genome-wide gene expression databases. The IMMPP resulted with no statistical significance (at the p −value = 0.01 level) for both FTC and PTC in all three cases (original dataset and two independent validation datasets) as expected. However, despite the statistical significance of the whole pathway, some molecules related to IMMPP in PTC resulted differentially expressed (depicted in Figure 7B). In the case of ATC, the IMMPP resulted dysregulated. However only two out of three experimental datasets (the original and one of the validation sets) reached statistical significance (p −value ≃ 10⁻⁸ and ≃ 10⁻⁵, respectively).