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. 2015 Mar 15;16:29. doi: 10.1186/s12882-015-0019-3

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© Nordholm et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Rapid development of hypocalcemia in total nephrectomized (NX) rats. Plasma Ca²⁺ concentrations in sham, NX, TPTX, and NX-TPTX rats. Plasma Ca²⁺ in the NX rats declined rapidly with development of significant hypocalcemia already within 60 minutes, as compared to sham rats (p < 0.01). TPTX resulted as expected in significant hypercalcemia (p < 0.05) within 60 minutes. The increase in plasma Ca²⁺ was significantly lower in NX-TPTX rats, than in TPTX rats, (p <0.05).