Figure 5. PAR-1 knockdown induces cytoprotection after MCAo.
(A, B) Representative images showing Fluoro-Jade-C positive cells indicating neuronal damage in mismatch and shRNA PAR-1 lentivirus injected animals. (C) Fluoro-Jade-C positive cells in a selected high power field. (D) PAR-1 shRNA injected animals show significantly reduced number of Fluoro-Jade-C positive cells. Scale bars (A, B) 200μm; (C) 100μm. (D) Data presented as mean ± SE (n=7). ***P<0.001, Students t-test for independent samples.