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. Author manuscript; available in PMC: 2016 Mar 28.
Published in final edited form as: Neuroscience. 2014 Sep 28;281:229–240. doi: 10.1016/j.neuroscience.2014.09.038

Figure 6. Effect of PAR-1 knockdown on neurological function.

Figure 6

Stereotaxic injection of PAR-1shRNA in animals 1 week before MCAo mediated significant recovery of neurological functions compared to PAR-1 misRNA injection. Animals were tested for forelimb withdrawal when suspended by tail, twisting of animal toward contralateral side and circling behavior based on a standard rodent grading system. Each neurological deficit accounted for 1 point for a total score of 3 points. Data presented as mean ± SE (n=7), ***P<0.001, Students t-test for independent samples.