Figure 5. Nanolipolee-007 decreased cellular proliferation and increased apoptosis by arresting melanoma cells in the G0/G1 phase of the cell cycle.
5A & 5B. Cell Proliferation and apoptosis rates following treatment of cultured cells with Nanolipolee-007. Cellular proliferation and apoptosis rates were measured for UACC 903 and 1205 Lu melanoma cells following treatment with 0.62 to 100 μmol/L of nanoliposome alone or abietic acid nanoliposome or Nanolipolee-007 for 24 hours. Data represent averages of at least 3 independent experiments; bars; S.E.M. 5C. Cell cycle analysis of cultured cells treated with Nanolipolee-007. Cell cycle distribution was measured by analyzing propidium iodide stained UACC 903 and 1205 Lu cells. Nanolipolee-007 treatment elevated the sub-G0/G1 and G0/G1 cell populations. Data represents an average of at least 2 independent experiments.