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. Author manuscript; available in PMC: 2015 Mar 29.
Published in final edited form as: JAMA Ophthalmol. 2013 Nov;131(11):1482–1485. doi: 10.1001/jamaophthalmol.2013.4681

Figure 1. Color Photographs, Fundus Autofluorescence Images, and Optical Coherence Tomographic Images.

Figure 1

Color photographs of the right (A) and left (B) eyes demonstrate bilateral macular atrophy (dotted inset) with pale optic nerves with peripapillary atrophy (white arrowheads) and diffuse retinal pigment epithelial changes. There was also a significant amount of asteroid hyalosis (black arrowhead) in the right eye (A). These magnified images of the macula highlight the graduated atrophy corresponding to the bright deposits around the fovea in both eyes (A and B) exhibiting a hyperreflective crystalline appearance. Fundus autofluorescence images of the right (C) and left (D) eyes demonstrate hypoautofluorescent areas suggestive of central atrophy with a surrounding ring of hyperautofluorescence corresponding to lipofuscin accumulation in the retinal pigment epithelium likely secondary to incomplete degradation of photoreceptor outer segments. These autofluorescence findings correlate with retinal optical coherence tomographic imaging of the right (E) and left (F) eyes showing diffuse outer retinal atrophy bilaterally.