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. 2015 Mar 22;13:23. doi: 10.1186/s12951-015-0085-5

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© Chaudhari et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic presentation of mechanism of action of SWCNTS-Ag and pSWCNTs-Ag. Our results demonstrated that SWCNTs-Ag down-regulate some of the genes associated with metabolism and outer membrane integrity, however they are still toxic to human cells at their bactericidal concentration (62.5 μg/mL). On the other hand, pegylation of SWCNTs-Ag (pSWCNTs-Ag) did not affect their antibacterial activity (62.5 μg/mL), but reduced their toxicity to human cells. In addition, pSWCNTs down-regulated the expression of genes associated with quorum sensing, biofilm formation and virulence in Salmonella.