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. 2015 Mar 28;15:41. doi: 10.1186/s12871-015-0021-0

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© Xie et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DAPT (an inhibitor of notch signaling pathway) administered before appearance of pain sensitivity significantly prevents the development of mechanical allodynia in SNI-induced neuropathic pain. A single administration of DAPT (50 μM, 10 μL, i.t.) was 0.5 h before SNI operation. The mechanical mechanical paw withdrawal threshold (PWT) was measured at 24 h before (baseline) as well as 7 d, 14 d, 21 d and 28 d after SNI or Sham operation. The data represent mean ± SD (n = 6 per group). ^*P < 0.05 versus Sham group; ^†P < 0.05 versus SNI group. SNI: spared nerve injury; BL: baseline; g: gram; d: day.