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. 2015 Mar 28;15:41. doi: 10.1186/s12871-015-0021-0

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© Xie et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Administration of Jagged-1 peptide, a ligand of notch signaling pathway, can induce neuropathic pain-like behavior in normal rats. The Jagged-1 (JAG-1) peptide (1, 10 and 100 μM) or control scrambled peptide (SC)-JAG-1 were i.t. administered to normal rats. The mechanical PWT was measured before (baseline) as well as 3 h, 6 h, 12 h, 24 h, 36 h and 48 h after JAG-1 or SC-JAG-1 administration. The data represent mean ± SD (n = 6 per group). *P < 0.05 versus SC-JAG-1 group, ^†P < 0.05 versus JAG‑1 1 μM group; ^‡P < 0.05 versus JAG‑1 10 μM group. BL: baseline; g: gram; h: hour.