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. 2015 Mar 25;12:56. doi: 10.1186/s12974-015-0262-3

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© Hopp et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Hippocampal immunohistochemistry against Arc was quantified across in brains perfused 30 min after rats were exposed to a novel context. (A) Representative slices of hippocampal Arc immunohistochemistry after 4 weeks of infusion with aCSF (top row) or LPS (bottom row) and treatment with vehicle (first column), dantrolene (middle column), or nimodipine (third column). (B) Quantification of Arc immunostaining in CA1, CA1, and DG. Data expressed as mean ± SEM. *Indicates a significant difference from treatment-matched aCSF controls, ^†indicates a significant difference from LPS + vehicle rats within the LPS group. Significance determined by P < 0.05. LPS lipopolysaccharide, aCSF artificial cerebrospinal fluid, DG dentate gyrus.