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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Leukemia. 2014 Sep 13;29(4):886–894. doi: 10.1038/leu.2014.298

Figure 2. Heatmap of baseline sample gene expression in Methotrexate responders versus nonresponders.

Figure 2

The top 126 genes by Z-score are displayed. Red shading indicates upregulation of mRNAs which are listed by official gene symbol at right. Samples are divided into 4 main groups from left to right, normal CD8+, normal Temra, patients with response to Methotrexate and lastly those not responding. Individual patient lanes are labeled by mutation type, type of response and trial accession number.

PR = partial response, CR = complete response, NC = no change, and PROG = progression