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. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Org Biomol Chem. 2015 Jan 21;13(3):909–915. doi: 10.1039/c4ob02031f

Scheme 1.

Scheme 1

A schematic representation of strategies for DNA modifications with a boronic acid: A). Enzymatic incorporation of boronic acid-modified nucleotides; B). Enzymatic incorporation of CBT modified nucleotides, followed by post-PCR modification; C). Enzymatic incorporation of trans-cyclooctene modified nucleotides, followed by Cu-free post-PCR modification