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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Arch Toxicol. 2014 Jun 25;89(7):1057–1070. doi: 10.1007/s00204-014-1302-y

Fig. 7.

Fig. 7

TMP and NAC inhibited arsenic-induced pro-inflammatory signals: p38 MAPK activation and COX-2 up-regulation in HK-2 cells. a, b Arsenic-induced p38 MAPK activation was verified by increased levels of phospho-Thr180/Tyr182 p38 MAPK (p-p38) expression, which was inhibited by NAC or TMP pretreatment. c, d Arsenic up-regulated COX-2 protein expression, while NAC and TMP suppressed COX-2 protein up-regulation. β-Actin was used as loading control. Values are mean ± SD (n = 3), **p < 0.01 versus Con