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. 2015 Mar 15;2015:176983. doi: 10.1155/2015/176983

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Copyright © 2015 Jaspreet Singh et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Mitochondrial complex subunit expression and levels in healthy control, adrenomyeloneuropathy (AMN), and adrenoleukodystrophy (ALD) patient-derived fibroblasts. Primary patient-derived skin fibroblasts from healthy control (CTL), AMN, and ALD were cultured as described in Section 2. mRNA (a) and protein (b) levels of mitochondrial complex subunits were significantly reduced in ALD patient-derived fibroblasts. (c) Densitometric ratio of mitochondrial subunit levels versus actin in western blots. Results represent the mean ± SD of triplicates from two different experiments. ^@ P < 0.05, ^@@ P < 0.01, and ^@@@ P < 0.001 ALD compared with AMN. ^* P < 0.05 AMN compared with CTL. COM: complex, NS: nonsignificant.