Table 1.
Effect of EESD on hole cross test.
| Treatment | Dose (mg/kg) | Number of holes crossed (% of inhibition) | ||||
|---|---|---|---|---|---|---|
| Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
| Control | 0.1 mL/mouse | 19 ± 1.58 | 17.60 ± 0.75 | 15.6 ± 0.93 | 13.4 ± 0.51 | 12.4 ± 0.51 |
| Diazepam | 1 | 21.2 ± 1.63 | 5.2 ± 1.16* (70.45) | 3.2 ± 0.37* (79.49) | 2.0 ± 0.45* (85.07) | 2.2 ± 0.74* (82.26) |
| EESD | 50 | 18.6 ± 1.69 | 12.6 ± 1.54* (28.41) | 10.2 ± 1.20* (34.62) | 7.2 ± 1.16* (46.27) | 4.2 ± 0.97* (66.13) |
| EESD | 100 | 20.4 ± 1.08 | 8.80 ± 0.49* (50.00) | 7.8 ± 1.02* (50.00) | 3.6 ± 0.81* (73.13) | 3.2 ± 0.86* (74.19) |
| EESD | 200 | 21 ± 0.84 | 6.0 ± 0.84* (65.91) | 2.0 ± 0.71* (87.18) | 1.6 ± 0.4* (88.06) | 1.2 ± 0.37* (90.32) |
Values are presented as the Mean ± SEM (n = 5). EESD = ethanolic extract of Scoparia dulcis; * P < 0.05 compared with the control group (two-way ANOVA followed by Bonferroni's test).