Table 2.
Effect of EESD on open field test.
| Treatment | Dose (mg/kg) | Number of squares crossed (% of inhibition) | ||||
|---|---|---|---|---|---|---|
| Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
| Control | 0.1 mL/mouse | 102.8 ± 2.99 | 93.2 ± 3.31 | 83 ± 3.67 | 67.8 ± 1.93 | 56.4 ± 2.79 |
| Diazepam | 1 | 97.4 ± 6.08 | 47.4 ± 1.66* (49.14) | 29.2 ± 2.46* (64.82) | 13.6 ± 2.09* (79.94) | 8.8 ± 0.86* (84.40) |
| EESD | 50 | 95.2 ± 5.83 | 59.4 ± 1.66* (36.27) | 43.4 ± 3.50* (47.71) | 27.6 ± 5.85* (59.29) | 19.6 ± 2.32* (65.25) |
| EESD | 100 | 99.4 ± 6.40 | 46.6 ± 9.32* (50) | 31.8 ± 4.87* (61.69) | 15.8 ± 2.91* (76.70) | 9.8 ± 2.76* (82.62) |
| EESD | 200 | 98.4 ± 5.34 | 39.6 ± 1.50* (57.51) | 20.6 ± 2.25* (75.18) | 7.6 ± 0.93* (88.79) | 3.20 ± 0.86* (94.33) |
Values are presented as the Mean ± SEM (n = 5). EESD = ethanolic extract of Scoparia dulcis; * P < 0.05 compared with the control group (two-way ANOVA followed by Bonferroni's test).