Table 1. Fourteen proteins were significantly enriched within the GSH metabolism pathway.
Uniprot accession no. | Gene IDs | Gene symbol | Protein description | CoverageA | 127/126B |
---|---|---|---|---|---|
P15144 | 290 | ANPEP | Aminopeptidase | 3.62 | 1.257 |
Q9Y2Q3-3 | 373156 | GSTK1 | Glutathione S-transferase kappa 1 | 15.89 | 0.885 |
P11413 | 2539 | G6PD | Glucose-6-phosphate 1-dehydrogenase | 31.46 | 0.498 |
P21266 | 2947 | GSTM3 | Glutathione S-transferase Mu 3 | 51.56 | 0.723 |
P78417 | 9446 | GSTO1 | Glutathione S-transferase omega-1 | 36.10 | 1.268 |
P00390-5 | 2936 | GSR | Glutathione reductase | 8.18 | 0.851 |
O75223 | 79017 | GGCT | Gamma-glutamylcyclotransferase | 21.28 | 0.631 |
P48637 | 2937 | GSS | Glutathione synthetase | 5.27 | 0.932 |
O75874 | 3417 | IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | 28.50 | 0.568 |
P48735 | 3418 | IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 40.49 | 0.643 |
P28838-2 | 51056 | LAP3 | Cytosol aminopeptidase | 33.20 | 0.777 |
P09211 | 2950 | GSTP1 | Glutathione S-transferase P | 52.86 | 1.612 |
P10620-2 | 4257 | MGST1 | microsomal glutathione S-transferase 1 | 28.74 | 0.932 |
P52209 | 5226 | PGD | 6-phosphogluconate dehydrogenase | 28.99 | 0.703 |
AData associated with the particular peptide from our proteomics analysis were matched to the peptide database.
BMCF-7 peptide samples of were labeled with TMT2-126 isobaric tags; MCF-7/ADR peptide samples of were labeled with TMT2-127 isobaric tags. The values of 127/126 represent the relative quantitation ratio of the DEPs in two cells.