Table 2. Some DEPs were identified in MCF-7/ADR compared to MCF-7.

Uniprot accession no.	Gene IDs	Gene symbol	Protein description	Coverage A	127/126B	Molecular Function	Biological Processes
P08727	3880	KRT19	Keratin, type I cytoskeletal 19	51.75	0.414	protein coding	response to stimuli; cell differentiation;
P13473	3920	LAMP2	lysosome-associated membrane glycoprotein 2	4.88	0.431	protein coding	transport; coagulation; response to stimuli
P11413	2539	G6PD	Glucose-6-phosphate 1-dehydrogenase	31.46	0.498	catalytic activity; protein coding	metabolic processes; regulation of biological processes;
P05787	3856	KRT8	Keratin, type II cytoskeletal 8	56.52	0.520	catalytic activity; protein coding	cell death; cell organization and biogenesis;
P04792	3315	HSPB1	Heat shock protein beta-1	43.90	0.551	enzyme regulator activity; protein coding	development; metabolic processes;
O75874	3417	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	28.50	0.568	catalytic activity; protein binding	metabolic processes; response to stimuli;
O75223	79017	GGCT	Gamma-glutamylcyclotransferase	21.28	0.631	catalytic activity; protein binding	regulation of biological processes; metabolic processes
P48735	3418	IDH2	Isocitrate dehydrogenase [NADP], mitochondrial	40.49	0.643	catalytic activity; nucleotide binding	metabolic processes
P08133-2	309	ANXA6	Isoform 2 of Annexin A6	33.39	1.501	metal ion binding; protein binding	transport; regulation of biological processes
P04083	301	ANXA1	Annexin A1	60.69	1.501	DNA binding; enzyme regulator activity;	defense response; regulation of biological processes;
P08758	308	ANXA5	Annexin A5	71.25	1.554	enzyme regulator activity; metal ion binding;	cell communication; regulation of biological processes;
P09211	2950	GSTP1	Glutathione S-transferase P	52.86	1.612	catalytic activity; protein binding;	response to stimuli; defense response;
P07355	302	ANXA2	Annexin A2	56.05	1.907	enzyme regulator activity; metal ion binding;	development; metabolic processes;
P08183	5243	ABCB1	Multidrug resistance protein 1	26.33	1.915	transporter activity; protein binding;	metabolic processes; transport;
Q01469	2171	FABP5	Fatty acid-binding protein	64.44	2.122	transporter activity; protein binding	metabolic processes; transport;
P07195	3945	LDHB	L-lactate dehydrogenase B chain	40.12	2.311	catalytic activity; protein coding	metabolic processes
P17096-2	3159	HMGA1	Isoform HMG-Y of High mobility group protein HMG-I/HMG-Y	17.71	3.484	DNA binding; catalytic activity; protein coding	metabolic processes; response to stimuli;

^AData associated with the particular peptides from our proteomics analysis were matched to the peptide database.

^BMCF-7 peptide samples were labeled with TMT²-126 isobaric tags; MCF-7/ADR peptide samples were labeled with TMT²-127 isobaric tags. The values of 127/126 represent the relative quantitation ratio of the DEPs in two cells.