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. 2014 Oct 23;97(1):191–200. doi: 10.1189/jlb.5A1113-626RR

Figure 7. Model of DA-mediated regulation of MDSC function and enhancement of anti-tumor immunity.

Figure 7.

Gr-1+CD115+ monocytic MDSCs express the D1-like receptors D1 and D5. The activation of D1 and D5 on MDSCs by DA and other D1-like receptor agonists inhibits ERK and JNK activation in response to IFN-γ stimulation, thereby inhibiting the production of NO, a pivotal mediator of the suppressive activity of MDSCs on T-cell proliferation and IFN-γ production. The attenuation of NO production by MDSCs leads to enhanced effector T-cell function and anti-tumor immunity. IFNGR, IFN-γ receptor.