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Effect of PMN modulators on UFPR1
| Modulator | EC50 (nM) | 95% | P value | |
|---|---|---|---|---|
| LPS | (+) | 20.8 | 14.3–30 | |
| (−) | 8.5 | 7.1–10.2 | 0.0013 | |
| TNF-α | (+) | 16.0 | 10.4–24.5 | |
| (−) | 8.5 | 7.1–10.2 | 0.001176 | |
| ENA-78 | (+) | 8.2 | 5.2–13.0 | |
| (−) | 12.2 | 8.8–17.0 | 0.007999 | |
| IL-1RA | (+) | 13.1 | 10.4–16.6 | |
| (−) | 13.3 | 11.5–15.3 | 0.696509 | |
| GM-CSF | (+) | 11.6 | 7.07–18.9 | |
| (−) | 9.2 | 7.4–11.3 | 0.730119 | |
| LXA4 | (+) | 10.2 | 8.7–12.0 | |
| (−) | n.s. | n.s. | n.s. | |
n.s., Not significant.
