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. 2015 Mar 20;6(1):124–149. doi: 10.3390/genes6010124

Figure 2.

Figure 2

Nxf1-dependent mRNA export. Nascent pre-mRNA is spliced by the spliceosome, and then AlyRef, Uap56, and THO assemble into TREX-1. Uap56 can bind pre-mRNA independently of THO and AlyRef, but it is unclear whether the Uap56 that docks to TREX-1 is distinct from the Uap56 that binds pre-mRNA before binding to TREX-1; i.e., model (i) versus model (ii). Spliced mRNA within TREX-1 recruits a NXf1-Nxt1 heterodimer that allows the mRNA to traverse the nuclear pore complex (NPC). INM: inner nuclear membrane, ONM: outer nuclear membrane.