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Crm1-dependent mRNA export. Several subsets of mRNA are exported by Crm1. There are four known pathways: (i) HuR-mediated; (ii) LRPPRC-mediated; (iii) Nxf3-mediated; and (iv) U snRNA export. Each pathway requires binding of Crm1 and RanGTP. Hydrolysis of GTP by RanGAP on the cytoplasmic face of the NPC releases mRNA into the cytoplasm.
