Table 1.
Demographics and clinical characterization of healthy controls and aMCI participants.
| Characteristic |
Controls |
aMCI 62.5 mg BID |
aMCI 125 mg BID |
aMCI 250 mg BID |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | p-Value | Mean | SD | p-Value | Mean | SD | p-Value | |
| Subjects | 17 | 20 | − | 17 | − | 17 | − | ||||
| Sex (M/F) | 9/8 | 9/11 | 0.719 | 6/11 | 0.381 | 6/11 | 0.381 | ||||
| Age (years) | 69.4 | 7.0 | 71.0 | 6.4 | 0.476 | 72.9 | 8.9 | 0.201 | 70.8 | 7.0 | 0.542 |
| Education (years) | 15.9 | 2.6 | 15.3 | 2.8 | 0.505 | 15.8 | 2.9 | 0.951 | 16.8 | 2.6 | 0.290 |
| CDR | 0 | 0.5 | − | 0.5 | − | 0.5 | − | ||||
| CDR sum of boxes | 0.03 | 0.1 | 0.88 | 0.5 | − | 1.0 | 0.6 | − | 1.2 | 0.6 | − |
| MMSE | 27.9 | 1.5 | 26.5 | 2.5 | 0.048 | 25.7 | 2.3 | 0.002 | 25.9 | 2.5 | 0.007 |
| LM delayed recall | 29.5 | 5.2 | 17.8 | 9.4 | <0.001 | 15.4 | 8.2 | <0.001 | 22.9 | 7.7 | 0.006 |
| BSRT delayed recall | 7.7 | 1.9 | 4.5 | 2.9 | <0.001 | 3.6 | 2.4 | <0.001 | 3.4 | 2.1 | <0.001 |
| Wechsler VPA delayed recall | 7.0 | 1.5 | 4.3 | 2.6 | <0.001 | 3.9 | 2.9 | <0.001 | 5.2 | 2.7 | 0.026 |
| BVRT | 5.8 | 1.8 | 4.9 | 1.6 | 0.091 | 4.5 | 1.5 | 0.026 | 5.2 | 1.7 | 0.338 |
CDR: Clinical Dementia Rating; MMSE: Mini Mental Status Exam; LM: Logical Memory Paragraph Recall; BSRT: Buschke Selective Reminding Test; VPA: Verbal Paired Associates; BVRT: Benton Visual Retention Test. p-Values are based on independent sample t-tests comparing each aMCI cohort to the control group.