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. 2015 Mar 21;5:12. doi: 10.1186/s13578-015-0002-5

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© Liu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Symptoms of acute DSS-induced colitis in WT and GHSR ^−/− mice. Acute colitis was induced in WT and GHSR^−/− mice by drinking 2% DSS for 7 days. Body weight change (A) and DAI score (B) which consist of weight loss, diarrhoea and faecal blood was given to each group daily to monitor the disease development. On day 7, mice were sacrificed, and disease evaluations were given at macroscopic level, including spleen weights (C) and colon shortening (D). Each point or bar represents the mean ± SEM; NS: no significance, *p < 0.05, **p < 0.01, and ***p < 0.005.