Normalized transepithelial electrical resistance (TEER) changes in human intestinal explants exposed to PT-gliadin or media alone. Explants obtained from non-celiac controls (NC), celiac patients with active disease (ACD), celiac patients in remission (RCD), and non-celiac patients with gluten sensitivity (GS). Explants were exposed to media alone (open symbols) or to PT-gliadin (filled symbols). NC (black triangle) explants demonstrated a greater increase in permeability (decrease in TEER) when exposed to PT-gliadin vs. exposure to media alone at 30, 60 and 120 min. RCD (blue diamond) explants demonstrated a greater increase in permeability when exposed to PT-gliadin vs exposure to media alone at 60 and 120 min. ACD (red circle) and GS (gold square) explants demonstrated a greater increase in permeability when exposed to PT-gliadin vs exposure to media alone at 30, 60, 90 and 120 min. Symbol denotes the median. Whiskers denote the 25th to 75th percentile. *
p < 0.05.