Table 3.

Covariate-adjusted associations between prenatal MeHg exposure (top half of table) and recent postnatal MeHg exposure (bottom half of table) and baroreflex sensitivity, heart rate variability and initial orthostatic hypotension in young healthy adults in the Seychelles. Results for each outcome are fit in separate models adjusting for either prenatal MeHg or recent postnatal MeHg exposure. For rMSSD and prenatal MeHg exposure only, there was a significant sex by prenatal MeHg interaction, for which the prenatal MeHg slope was positive (Coef: 1.99) and significant (P = 0.014) for males only.

Variables	BRS			E/I ratio			PNN50			rMSSD			LF/HF ratio			Max30/Min15 ratio
	Coef	SE	P	Coef	SE	P	Coef	SE	P	Coef	SE	P	Coef	SE	P	Coef	SE	P
Prenatal MeHg exposure
Prenatal MeHg	0.176	0.192	0.362	0.004	0.006	0.548	0.001	0.002	0.551	0.784	0.613	0.205	0.006	0.008	0.486	−0.004	0.007	0.534
Birth weight	0.684	1.579	0.666	−0.012	0.049	0.806	−0.004	0.015	0.775	0.940	4.901	0.848	−0.062	0.065	0.340	−0.015	0.050	0.758
Current BMI	−0.423	0.171	0.015	−0.004	0.005	0.478	−0.001	0.002	0.422	−0.871	0.537	0.109	−0.003	0.007	0.683	0.001	0.007	0.873
Male (vs. female)	0.548	1.558	0.726	−0.016	0.049	0.744	0.012	0.015	0.424	5.120	4.869	0.296	−0.007	0.065	0.917	−0.041	0.054	0.449
n	81			85			82			82			79			72
Recent postnatal MeHg exposure
Recent postnatal MeHg	−0.072	0.164	0.664	−0.002	0.005	0.687	0.001	0.002	0.686	0.136	0.506	0.789	−0.011	0.007	0.116	0.006	0.006	0.277
Birth weight	0.610	1.665	0.715	0.003	0.046	0.947	−0.004	0.016	0.819	2.047	5.052	0.687	−0.039	0.067	0.560	−0.003	0.053	0.956
Current BMI	−0.447	0.180	0.015	−0.003	0.005	0.558	−0.001	0.002	0.545	−0.693	0.557	0.218	−0.003	0.007	0.687	0.002	0.007	0.739
Male (vs. female)	0.726	1.815	0.690	−0.039	0.050	0.433	0.010	0.017	0.562	5.743	5.435	0.294	0.021	0.073	0.778	−0.053	0.057	0.355
n	73			77			76			76			73			68

BRS: baroreflex sensitivity; E/I ratio: ratio of the mean expiratory/inspiratory RR intervals; PNN50: relative numbers of normal-to-normal intervals which are shorter by more than 50 ms than the immediately following normal-to-normal intervals; rMSSD: root mean of the squared sum of successive interval differences; LF/HF ratio: low frequency/high frequency component ratio; Max30/Min15 ratio: ratio between the longest RR interval 30 s after standing and the shortest RR interval at 15 s; P refers to p value.