Table 2.
Selected differentially expressed genes in fast muscle of exercised zebrafish that participate in the contractile activation of skeletal muscle fibers
| Gene name gene description | FC | Gene name gene description | FC | ||
|---|---|---|---|---|---|
| Muscle contraction | Muscle growth and development | ||||
| capn8 | Calpain 8 | 4.11 | fgf20 | Fibroblast growth factor 20 | 8.94 |
| actn4 | Actinin, alpha 4 | 3.99 | hdac6 | Histone deacetylase 6 | 6.42 |
| myh11 | Myosin, heavy chain 11, smooth muscle | 3.63 | fgf18 | Fibroblast growth factor 18 | 6.30 |
| camk2n2 | Ca/calmodulin-dependent protein kinase II inhibitor 2 | 3.38 | wnt10a | Wingless-type MMTV integration site, 10A | 6.25 |
| pvalb | Parvalbumin | 3.24 | pax3 | Paired box 3 | 6.21 |
| tnni2 | Troponin I type 2 (skeletal, fast) | 3.12 | tgfb2 | Transforming growth factor, beta 2 | 5.35 |
| capn3 | Calpain 3, (p94) | 3.08 | nog | Noggin | 4.90 |
| nfatc4 | Nuclear factor of activated T-cells, calcineurin-dep. 4 | 3.08 | esrra | Estrogen-related receptor alpha | 4.73 |
| capn2 | Calpain 2, (m/II) large subunit | 2.92 | wnt7a | Wingless-type MMTV integration site, 7A | 4.60 |
| tmod4 | Tropomodulin 4 (muscle) | 2.79 | mstn | Myostatin | 4.41 |
| nfatc1 | Nuclear factor of activated T-cells, , calcineurin-dep. 1 | 2.76 | foxa1 | Forkhead box A1 | 4.22 |
| capzb | Capping protein (actin filament) muscle Z-line, beta | 2.75 | fgfr2 | Fibroblast growth factor receptor 2 | 4.05 |
| casq1 | Calsequestrin 1 (fast-twitch, skeletal muscle) | 2.68 | shh | Sonic hedgehog | 3.78 |
| myl2 | Myosin, light chain 2, regulatory, cardiac, slow | 2.64 | fzd2 | Frizzled family receptor 2 | 3.08 |
| ppp3cc | Protein phosphatase 3, catalytic subunit, gamma | 2.61 | pik3c2b | Phosphatidylinositol-4-p- 3-kinase c2b | 3.06 |
| capn5 | Calpain 5 | 2.60 | fgf13 | Fibroblast growth factor 13 | 3.01 |
| ttn | Titin | 2.58 | mapk1 | Mitogen-activated protein kinase 1 | 3.00 |
| ppp3ca | Protein phosphatase 3, catalytic subunit, alpha isozyme | 2.52 | fzd10 | Frizzled family receptor 10 | 2.94 |
| mylpf | Myosin light chain, phosphorylatable, fast skel. muscle | 2.26 | ihh | Indian hedgehog | 2.91 |
| mybph | Myosin binding protein H | 2.17 | fzd8 | Frizzled family receptor 8 | 2.87 |
| capn10 | Calpain 10 | 2.15 | esrrb | Estrogen-related receptor beta | 2.61 |
| cacna1s | Calcium channel, voltage-dependent, L type, alpha 1S | 2.11 | bmpr1a | Bone morphogenetic protein receptor, IA | 2.58 |
| camk2a | Calcium/calmodulin-dependent protein kinase II alpha | 1.98 | ngf | Nerve growth factor (beta polypeptide) | 2.55 |
| camk2d | Calcium/calmodulin-dependent protein kinase II delta | 1.97 | igf1r | Insulin-like growth factor 1 receptor | 2.53 |
| nfatc3 | Nuclear factor of activated T-cells, calcineurin-dep. 3 | 1.92 | bmp1 | Bone morphogenetic protein 1 | 2.46 |
| acta2 | Actin, alpha 2, smooth muscle, aorta | 1.92 | dvl1 | Dishevelled, dsh homolog 1 (Drosophila) | 2.43 |
| mylk | Myosin light chain kinase | 1.87 | smad2 | SMAD family member 2 | 2.40 |
| tpm4 | Tropomyosin 4 | 1.78 | bmp4 | Bone morphogenetic protein 4 | 2.38 |
| myl9 | Myosin, light chain 9, regulatory | 1.77 | igfbp7 | Insulin-like growth factor binding protein 7 | 2.36 |
| ryr1 | Ryanodine receptor 1 (skeletal) | 1.77 | esrrg | Estrogen-related receptor gamma | 2.36 |
| tpm1 | Tropomyosin 1 (alpha) | 1.71 | bmpr1b | Bone morphogenetic protein receptor, IB | 2.27 |
| atp2a1 | ATPase, Ca transporting, cardiac muscle, fast twitch 1 | 1.70 | erbb2 | v-erb-b2 erythroblastic leukemia. 2 | 2.27 |
| actc1 | Actin, alpha, cardiac muscle 1 | 1.68 | mapk13 | Mitogen-activated protein kinase 13 | 2.23 |
| cacng1 | Calcium channel, voltage-dependent, gamma subunit 1 | 1.61 | fst | Follistatin | 2.17 |
| myl12b | Myosin, light chain 12B, regulatory | −1.59 | mapk8 | Mitogen-activated protein kinase 8 | 2.12 |
| s100a4 | S100 calcium binding protein A4 | −1.63 | smad6 | SMAD family member 6 | 2.06 |
| calm1 | Calmodulin 1 (phosphorylase kinase, delta) | −2.04 | fgfr1 | Fibroblast growth factor receptor 1 | 1.96 |
| actg2 | Actin, gamma 2, smooth muscle, enteric | −3.87 | irs2 | Insulin receptor substrate 2 | 1.91 |
| tnnt3 | Troponin T type 3 (skeletal, fast) | −7.01 | runx2 | Runt-related transcription factor 2 | 1.90 |
| Cytoskeleton | igfbp1 | Insulin-like growth factor binding protein 1 | 1,89 | ||
| ank2 | Ankyrin 2, neuronal | 11.01 | irs1 | Insulin receptor substrate 1 | 1.78 |
| plec | Plectin | 3.31 | acvr2b | Activin A receptor, type IIB | 1.74 |
| myoz1 | Myozenin 1 | 2.41 | tgfb1 | Transforming growth factor, beta 1 | 1.71 |
| myoz2 | Myozenin 2 | 2.28 | mef2d | Myocyte enhancer factor 2D | 1.71 |
| dag1 | Dystroglycan 1 (dystrophin-associated glycoprotein 1) | 2.26 | hdac4 | Histone deacetylase 4 | 1.71 |
| itgb4 | Integrin, beta 4 | 1.99 | igfbp3 | Insulin-like growth factor binding protein 3 | 1.66 |
| itga2b | Integrin, alpha 2b | 1.95 | mef2a | Myocyte enhancer factor 2A | 1.66 |
| dmd | Dystrophin | 1.94 | igf2 | Insulin-like growth factor 2 | 1.61 |
| filip1 | Filamin A interacting protein 1 | 1.88 | pten | Phosphatase and tensin homolog | −1.54 |
| sntb1 | Syntrophin, beta 1 (dystrophin-associated protein A1) | 1.78 | mef2c | Myocyte enhancer factor 2C | −1.59 |
| vim | Vimentin | 1.61 | egfr | Epidermal growth factor receptor | −2.13 |
| lmna | Lamin A/C | −1.51 | id3 | Inhibitor of DNA binding 3 | −2.39 |
| dtnbp1 | Dystrobrevin binding protein 1 | −1.76 | srf | Serum response factor | −2.68 |
| flnc | Filamin C, gamma | −1.88 | mapk14 | Mitogen-activated protein kinase 14 | −2.78 |
| Neuromuscular junction | Extracelular matrix | ||||
| ache | Acetylcholinesterase | 8.86 | col8a2 | Collagen, type VIII, alpha 2 | 12.06 |
| vamp1 | Vesicle-associated membrane prot. 1 (synaptobrevin1) | 3.78 | lamc3 | Laminin, gamma 3 | 10.06 |
| chrm2 | Cholinergic receptor, muscarinic 2 | 3.65 | col16a1 | Collagen, type XVI, alpha 1 | 6.17 |
| snap25 | Synaptosomal-associated protein, 25kDa | 3.08 | col1a2 | Collagen, type I, alpha 2 | 3.12 |
| scn4b | Sodium channel, voltage-gated, type IV, beta subunit | 3.01 | bgn | Biglycan | 2.98 |
| syn2 | Synapsin II | 2.70 | loxl2 | Lysyl oxidase-like 2 | 2.92 |
| syt1 | Synaptotagmin I | 2.22 | mmp14 | Matrix metallopeptidase 14 | 2.69 |
| rims2 | Regulating synaptic membrane exocytosis 2 | 1.93 | tnc | Tenascin C | 2.53 |
| scnm1 | Sodium channel modifier 1 | 1.65 | mmp10 | Matrix metallopeptidase 10 (stromelysin 2) | 2.06 |
| syncrip | Synaptotagmin binding, cytoplasmic RNA interact. pro. | −1.54 | sdcbp | Syndecan binding protein (syntenin) | −2.26 |
Data are shown as fold change (FC).
Functional categories are indicated in bold.