Table 3.
Selected differentially expressed genes in fast muscle of exercised adult zebrafish that participate in angiogenesis, immune-related processess and metabolism
| Gene name gene description | FC | Gene name gene description | FC | ||
|---|---|---|---|---|---|
| Angiogenesis | Energy metabolism | ||||
| klf2 | Kruppel-like factor 2 (lung) | 8.52 | cpt1a | Carnitine palmitoyltransferase 1A (liver) | 5.23 |
| robo2 | Roundabout, axon guidance receptor, homolog 2 (Drosophila) | 4.30 | pfkm | Phosphofructokinase, muscle | 3.84 |
| angpt2 | Angiopoietin 2 | 3.90 | prkaaq | Protein kinase, AMP-activated, alpha 1 cat. | 3.66 |
| angptl3 | Angiopoietin-like 3 | 3.47 | elovl4 | ELOVL fatty acid elongase 4 | 3.65 |
| efna3 | Ephrin-A3 | 3.45 | prkag1 | Protein kinase, AMP-activated, gamma 1 catalytic subunit | 3.50 |
| gata1 | GATA binding protein 1 (globin transcription factor 1) | 3.00 | acadl | Acyl-CoA dehydrogenase, long chain | 3.20 |
| epha4 | EPH receptor A4 | 2.96 | ppard | Peroxisome proliferator-activated receptor d | 3.19 |
| nrp1 | Neuropilin 1 | 2.89 | aldoa | Aldolase A, fructose-bisphosphate | 3.18 |
| mmp14 | Matrix metallopeptidase 14 (membrane-inserted) | 2.69 | mcat | Malonyl CoA:ACP acyltransferase (mitochondrial) | 3.14 |
| nos1 | Nitric oxide synthase 1 (neuronal) | 2.65 | slc27a2 | Solute carrier family 27 (fatty acid transporter), member 2 | 3.10 |
| notch1 | Notch 1 | 2.60 | prkab1 | Protein kinase, AMP-activated, beta 1 non-catalytic subunit | 3.06 |
| sema3f | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 2.57 | mb | Myoglobin | 2.95 |
| slit3 | Slit homolog 3 (Drosophila) | 2.53 | cox7c | Cytochrome c oxidase subunit VIIc | 2.85 |
| amot | Angiomotin | 2.34 | ppara | Peroxisome proliferator-activated receptor alpha | 2.77 |
| hey2 | Hairy/enhancer-of-split related with YRPW motif 2 | 2.20 | tfb2m | Transcription factor B2, mitochondrial | 2.42 |
| tp63 | Tumor protein p63 | 2.16 | fbp1 | Fructose-1,6-bisphosphatase 1 | 2.39 |
| mmp10 | Matrix metallopeptidase 10 (stromelysin 2) | 2.06 | g6pc | Glucose-6-phosphatase, catalytic subunit | 2.38 |
| s1pr1 | Sphingosine-1-phosphate receptor 1 | 2.03 | pdha1 | Pyruvate dehydrogenase (lipoamide) alpha 1 | 2.24 |
| ephb4 | EPH receptor B4 | 1.97 | ckm | Creatine kinase, muscle | 2.24 |
| nr2f2 | Nuclear receptor subfamily 2, group F, member 2 | 1.95 | fh | Fumarate hydratase | 2.20 |
| efnb3 | Ephrin-B3 | 1.94 | ogdh | Oxoglutarate hydrogenase (lipoamide) | 2.19 |
| hif3a | Hypoxia inducible factor 3, alpha subunit | 1.92 | gapdh | Glyceraldehyde-3-phosphate dehydrogenase | 2.19 |
| epha7 | EPH receptor A7 | 1.91 | adh5 | Alcohol dehydrogenase 5 (class III) | 2.18 |
| angptl2 | Angiopoietin-like 2 | 1.90 | cox5a | Cytochrome c oxidase subunit Va | 2.12 |
| nos2 | Nitric oxide synthase 2, inducible | 1.85 | pgk1 | Phosphoglycerate kinase 1 | 2.02 |
| cdc42ep2 | CDC42 effector protein (Rho GTPase binding) 2 | 1.83 | fads6 | Fatty acid desaturase 6 | 1.99 |
| efna2 | Ephrin-A2 | 1.83 | mdh2 | Malate dehydrogenase 2, NAD (mitochondrial) | 1.97 |
| nr2f1 | Nuclear receptor subfamily 2, group F, member 1 | 1.83 | cox6a2 | Cytochrome c oxidase subunit VIa polypeptide 2 | 1.97 |
| jag1 | Jagged 1 | 1.80 | ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 1.94 |
| slit2 | Slit homolog 2 (Drosophila) | 1.79 | fabp3 | Fatty acid binding protein 3, muscle and heart | 1.94 |
| hey1 | Hairy/enhancer-of-split related with YRPW motif 1 | 1.78 | slcad | Solute carrier family 2 (facilitated glucose transporter), member 2 | 1.92 |
| hif1an | Hypoxia inducible factor 1, alpha subunit inhibitor | 1.73 | atp5h | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d | 1.91 |
| foxc1 | Forkhead box C1 | 1.68 | ucp3 | Uncoupling protein 3 (mitochondrial ) | 1.88 |
| efnb2 | Ephrin-B2 | 1.63 | cpt2 | Carnitine palmitoyltransferase 2 | 1.86 |
| jag2 | Jagged 2 | 1.54 | ndufb1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 1.82 |
| vegfc | Vascular endothelial growth factor C | 1.36 | ckmt2 | Creatine kinase, mitochondrial 2 (sarcomeric) | 1.82 |
| dll1 | Delta-like 1 (Drosophila) | −1.25 | mdh1 | Malate dehydrogenase 1, NAD (soluble) | 1.77 |
| rac1 | Ras-related C3 botulinum toxin substrate 1 | −1.57 | sdha | Succinate dehydrogenase complex, subunit A, | 1.74 |
| rock2 | Rho-associated, coiled-coil containing protein kinase 2 | −1.61 | mt-atp6 | ATP synthase F0 subunit 6 | 1.70 |
| notch2 | Notch 2 | −1.89 | acacb | Acetyl-CoA carboxylase beta | 1.70 |
| cdc42 | Cell division cycle 42 | −1.97 | ucp2 | Uncoupling protein 2 (mitochondrial) | 1.68 |
| aggf1 | Angiogenic factor with G patch and FHA domains 1 | −2.10 | atp5o | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | 1.68 |
| Immune-related factors | eno1 | Enolase 1, (alpha) | 1,68 | ||
| traf6 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase | 10.78 | cox4i1 | Cytochrome c oxidase subunit IV isoform 1 | 1.68 |
| il17D | Interleukin 17D | 6.51 | cox7a2l | Cytochrome c oxidase subunit VIIa polypeptide 2 like | 1.67 |
| ptgs1 | Prostaglandin-endoperoxide synthase 1 | 5.81 | atp5f1 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 | 1.65 |
| irak1bp1 | Interleukin-1 receptor-associated kinase 1 BP 1 | 4.98 | nrf1 | Nuclear respiratory factor 1 | 1.62 |
| irf3 | Interferon regulatory factor 3 | 4.60 | ldhb | Lactate dehydrogenase B | 1.60 |
| il29ra | Interleukin 20 receptor, alpha | 3.91 | adipor2 | Adiponectin receptor 2 | 1.56 |
| il12b | Interleukin 12B | 3.68 | lpl | Lipoprotein lipase | −1.51 |
| il11ra | Interleukin 11 receptor, alpha | 3.24 | eifsb4 | Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | −1.58 |
| ptgr1 | Prostaglandin reductase 1 | 3.21 | gpi | Glucose-6-phosphate isomerase | −1.76 |
| ptgds | Prostaglandin D2 synthase 21kDa (brain) | 3.18 | ndufaf4 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 | −1.88 |
| ptgis | Prostaglandin I2 (prostacyclin) synthase | 2.87 | aldoc | Aldolase C, fructose-bisphosphate | −2.03 |
| il13ra2 | Interleukin 13 receptor, alpha 2 | 2.54 | pkm | Pyruvate kinase, muscle | −2.24 |
| il20 | Interleukin 20 | 2.44 | hk2 | Hexokinase 2 | −2.36 |
| tnfrsf19 | Tumor necrosis factor receptor superfamily, member 19 | 2.43 | Protein synthesis and degradation | ||
| nkrf | NFKB repressing factor | 1.77 | pdk2 | Pyruvate dehydrogenase kinase, isozyme 2 | 6.87 |
| il17rd | Interleukin 17 receptor D | 1.74 | fbxo32 | F-box protein 32 | 6.01 |
| mst1 | Macrophage stimulating 1 (hepatocyte growth factor-like) | 1.66 | pdk1 | Pyruvate dehydrogenase kinase, isozyme 1 | 2.19 |
| mif | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | −1.50 | foxo3 | Forkhead box O3 | 2.08 |
| ilf3 | Interleukin enhancer binding factor 3, 90kDa | −1.77 | trim63 | Tripartite motif containing 63, E3 ubiquitin protein ligase | 2.02 |
| ptges3 | Prostaglandin E synthase 3 (cytosolic) | −2.29 | rps6ka1 | Ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 1.96 |
| il21r | Interleukin 21 receptor | −2,59 | eif4e | Eukaryotic translation initiation factor 4E | −1,89 |
| irak4 | Interleukin-1 receptor-associated kinase 4 | −2,68 | eif4ebp1 | Eukaryotic translation initiation factor 4E binding protein 1 | −2,01 |
Data are shown as fold change (FC).
Functional categories are indicated in bold.