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. 2015 Feb 19;13:13. doi: 10.1186/s12915-015-0122-8

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© Buzi et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Disturbances and their impact on the dynamics of a two-stage cell lineage. Stem or committed progenitor (CP) cells can self-renew or differentiate to terminally differentiated (TD) cells. The processes of cell division, renewal or differentiation, and cell death can be affected by a number of biologically relevant disturbances that affect the steady state populations of terminal and stem or CP cells.