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. 2014 Dec 22;26(4):817–829. doi: 10.1681/ASN.2013101137

Figure 1.

Figure 1.

Characterization of endothelial TβRII heterozygote mice. (A) Genotyping of pups from TGF-βRIIFlox/Flox and Tie2-Cre: TGF-βRIIFlox/WT matings. Tail PCR genotyping analysis. The top panel shows detection of floxed and WT fragments. The bottom panel shows detection of Cre-transgene. (B) Real-time PCR analysis for TβRII mRNA expression in kidney ECs isolated from TβRIIendo+/+ and TβRIIendo+/− mice (n=4). *P<0.05, TβRII+/+ versus TβRII+/−. (C) Western blot for Smad2 signaling in kidney ECs. WT, wild type; Cont, control.