Figure 2.

Pkd1-dependent cystic phenotype is reduced in Itgb1-KO mice. (A) Histologic periodic acid–Schiff-stained preparations from representative kidneys of littermates of indicated ages. The progression of the disease is blunted by the lack of Intβ1, which is shown in a representative 15-month specimen from a DKO mouse at the bottom. (B) Progressive enlargement of Pkd1-ablated kidneys determined as the percentage of body weight is prevented in the absence of Intβ1 expression. (C) The cystic area of DKO kidneys does not increase in time. (D) Ablation of Intβ1 in Pkd1 KO kidneys preserves the normal renal function, which was determined by BUN levels. (E) DKO mice have a normal survival rate. Numbers within each columns denote the number of animals (n) analyzed per group. Statistical comparison by two-way ANOVA with Bonferroni post-test. *P<0.001; ^#P<0.002; ^@P<0.04.