Table 1.
Proinflammatory cytokine and chemokine expression in kidneys of WT mice treated with cisplatin or cisplatin+FTY720
| Cisplatin | Cisplatin+FTY720 | |
|---|---|---|
| CXCL1 | 60.9±26.4a | 13.7±6.9 |
| MCP-1 | 83.1±30.9a | 18.2±6.7 |
| IL1-β | 12.3±4.3a | 1.2±0.7b |
| IL-6 | 216.9±74.2a | 62.7±24.1b |
| TNF-α | 77.7±27.4a | 28.7±12.3 |
Doses of cisplatin and cisplatin+FTY720 as in Figure 1. mRNA expression (72 hours after cisplatin) relative to glyceraldehyde 3-phosphate dehydrogenase expressed as fold changes compared with vehicle. Values are the mean±SEM. n=6–8 in each group.
a
P<0.05 compared with vehicle.
b
P<0.05 compared with cisplatin.