Table 1.
Baseline demographic and clinical characteristics of the patients with renal involvement
| Variable | RTX Group (n=51) | CYC/AZA Group (n=51) | P Value |
|---|---|---|---|
| Age (yr) mean (SD) | 56 (15) | 54 (13) | 0.32 |
| Sex (%) | 0.32 | ||
| Men | 47 | 57 | |
| Women | 53 | 43 | |
| Race (%) | |||
| White | 94 | 94 | |
| Black | 4 | 4 | |
| Other | 2 | 2 | |
| Body mass index (kg/m2) mean (SD) | 28 (5) | 29 (6) | 0.56 |
| Type of AAV (%) | 0.67 | ||
| GPA | 69 | 65 | |
| MPA | 31 | 35 | |
| ANCA type (%) | 0.69 | ||
| PR3 | 59 | 55 | |
| MPO | 41 | 45 | |
| Newly diagnosed GN at enrollment (%) | 51 | 63 | 0.23 |
| Pre-enrollment disease duration in those with relapsed GN (yr) mean (SD) | 5.7 (4.5) | 4.3 (4.1) | 0.28 |
| Pre-enrollment exposure to CYC in patients with relapsed GN (%) | 84 | 68 | 0.29 |
| BVAS/WG (0–67) mean (SD) | 8.7 (2.74) | 8.7 (3.51) | 0.54 |
| Renal BVAS/WG (0–7) mean (SD) | 4.6 (1.44) | 4.5 (1.42) | 0.68 |
| Serum creatinine at entry (mg/dl) mean (SD) | 2.02 (0.92) | 1.71 (0.70) | 0.11 |
| MDRD eGFR at entry (ml/min per 1.73 m2) mean (SEM) | 41.4 (3.3) | 50.4 (3.3) | 0.05 |
| MDRD GFR>60 ml/min per 1.73 m2 (%) | 18 | 34 | 0.19 |
| MDRD GFR=30–60 ml/min per 1.73 m2 (%) | 47 | 39 | |
| MDRD GFR<30 ml/min per 1.73 m2 (%) | 35 | 27 | |
| Vasculitis Damage Index (0–64) mean (SD) | 1.1 (1.39) | 0.8 (1.17) | 0.34 |
| C-reactive protein (mg/dl) median and quartiles 1–3 | 1.4 (0.5–4.6) | 2.0 (0.7–5.1) | 0.23 |
| Erythrocyte sedimentation rate (mm/h) mean (SD) | 43.2 (25.85) | 53.7 (29.27) | 0.07 |
| Serum albumin (g/dl) mean (SD) | 3.54 (0.45) | 3.57 (0.45) | 0.51 |
| Number of organs involved mean (SD) | 3.2 (1.17) | 3.2 (1.39) | 0.63 |
| Alveolar hemorrhage (%) | 35 | 29 | 0.53 |