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. 2015 Apr 1;142(7):1357–1367. doi: 10.1242/dev.118802

Fig. 1.

Fig. 1.

Enhanced BMP signaling through a constitutively active form of BMPR1A causes neonatal lethality. (A) Survival curve for control (blue, n=14) and ca-Bmpr1a:P0-Cre mice (red, n=13) after cesarean section at E18.5. (B) Type 2 mutants exhibited abdominal distension (arrow). (C) Gastrointestinal tracts of type 2 mutants were filled with air bubbles, whereas controls and type 1 mutants had milk in their stomachs. (D) Newborn type 1 and type 2 mutants displayed short broad snouts and hypertelorism. (E) Western blot analysis measuring the levels of pSMAD1/5/9 in control, type 1 and type 2 mutant nasal tissues. GAPDH was used as a loading control. Results for pSMAD1/5/9 were quantified by densitometry (bar graph). All data are represented as mean±s.d. (n=4). *P<0.05, **P<0.005 (Student's t-test). Scale bars: 1 mm.