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. 2015 Apr 1;142(7):1254–1266. doi: 10.1242/dev.119735

Fig. 4.

Fig. 4.

Gas1 knockout kidneys are hypoplastic and show disorganization of the nephrogenic zone. (A-D) Histology of Gas1 knockout kidneys at stage E15.5. Kidneys are normal and adequately sized with condensing mesenchyme (yellow line) and two renal vesicles (green line) surrounding a ureteric bud branch (black line). het, heterozygous. Scale bars: 50 µm (low power), 10 µm (high power). (E-H) Histology at stage P0. Gas1 knockout kidneys are hypoplastic. Condensed mesenchyme is reduced and only a single renal vesicle is present. (I) The longitudinal diameters of kidney sections including the papilla at various stages. ko, knockout; ctrl, heterozygous knockout. Data show the mean±s.d., n≥4; ns, not significant; **P<0.01; ***P<0.001. (J) The numbers of glomeruli in Gas1 knockout and control kidneys at P0. Data show the mean±s.d.; **P<0.01.