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. 2014 Jul 29;20(4):447–453. doi: 10.1038/mp.2014.74

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Anatomical details between the ¹H-magnetic resonance spectroscopy (¹H-MRS) volume-of-interest (VOI) and functional magnetic resonance imaging (fMRI) signal change. (a) Brain regions that showed a significant effect of oxytocin on the fMRI signal associated with socio-communication behavior (non-verbal communication information-based judgment (NVJ)-specific activity>verbal communication information-based judgment (VJ)) (that is, the ventromedial prefrontal/anterior cingulate cortices (vmPFC/ACC) and the dorsomedial prefrontal cortex (dmPFC), P<0.001, uncorrected for the purpose of presentation) are overlaid on orthogonal slices. Gray squares represent the ¹H-MRS VOIs (20 × 20 × 20 mm). Representative spectrum of (b) oxytocin and (c) placebo sessions in a study participant as fit by the LCModel.