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. 2014 Dec 19;15(1):1144. doi: 10.1186/1471-2164-15-1144

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© O’Reilly et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The genes determining TRAIL-response-tend to be upstream regulators of components of cell death and cell survival signal transduction pathways. The figure shows direct (solid lines) and indirect interactions (dashed lines) amongst components of the cell death and survival signal transduction pathways. Genes from the 350 gene panel are coloured grey. Lines with arrowheads indicate functional interaction, such as regulation of expression or activity, while lines without arrowheads indicate protein-protein interactions.