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. 2014 Dec 19;15(1):1144. doi: 10.1186/1471-2164-15-1144

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© O’Reilly et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The known core components and regulators of the TRAIL apoptotic machinery do not predict TRAIL sensitivity with a high degree of sensitivity and specificity. (A) The selected 26 core component genes and regulators of the TRAIL apoptotic. (B) Performance of the 26 “TRAIL effectors” as a classifier assessed using the same approach as for the whole transcriptome (workflow shown in Additional file 1: Figure S1). The 26 core effectors predicted TRAIL sensitivity poorly (AUC = 0.46). Removal of any of the core effectors caused a decrease in the model’s ability to predict sensitivity to TRAIL.