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. 2015 Mar 27;15:189. doi: 10.1186/s12885-015-1230-0

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© He et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pathological changes.(A) Colons were excised 10 weeks after AOM injection (left) and were longitudinally opened (right). (B) Colons were excised 20 weeks after AOM injection and were stained with H&E. (C) Squamous metaplasia, adenoma, high grade intraepithelial neoplasia and adenocarcinoma were found in WT group and NPC1L1^−/− group. (Scale bars represent 400 μm.) (D) NPC1L1^−/− mice had a lower ratio of malignant tumor/tumor than WT mice. *p < 0.05.