Table 1.
Expression pattern of HLA-G-related molecules on cells at the maternal–fetal interface.
| Cell types | HLA-G isoforms (reference) | HLA-G receptors (reference) |
|||
|---|---|---|---|---|---|
| ILT2 | ILT4 | KIR2DL4 | |||
| EVTs | HLA-G1 (39, 40) | Neg (47) | Neg (47) | n.t. | |
| shed HLA-G1 (40, 42) | |||||
| HLA-G2 (42) | |||||
| HLA-G5 (41) | |||||
| HLA-G6 (43) | |||||
| Syncytiotrophoblasts | HLA-G5 (33) | Neg (47) | Neg (47) | n.t. | |
| Endothelial cells | Maternal endothelium | n.t. | Neg (47) | Neg (47) | n.t. |
| Fetal vessels | n.t. | Neg (47) | n.t. | n.t. | |
| Endometrial stromal cells | n.t. | Pos (47) | Neg (47) | n.t. | |
| dNK | Total CD56+ | Neg (48) | Posowlow (49) | Neg (49) | Pos (49–51) |
| CD4+ | Total CD4+ | n.t. | Pos (52) | n.t. | Pos (52) |
| CD4+HLA-G+ | HLA-G1 (53, 54) | n.t. | n.t. | n.t. | |
| CD8+ | Total CD8+ | n.t. | n.t. | n.t. | n.t. |
| CD8+HLA-G+ | HLA-G1 (53) | n.t. | n.t. | n.t. | |
| Macrophages | CD14+CD163+ | Neg (55) | Pos (50, 56) | Pos (50, 56) | n.t. |
| DCs | DC-SIGN+ | HLA-G1 (57) | n.t. | Pos (57) | n.t. |
| DC-10 | HLA-G1 (53) | Pos (53) | Pos (53) | n.t. | |
The indicated markers have been tested on cells at the maternal–fetal interface and demonstrated to be expressed (Pos) or not (Neg).
The indicated markers have not been tested yet (n.t.).