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Synthesis of rac-D-2: (i) acetic anhydride, 120 °C; (ii) water, reflux; (iii) rac-3-amino-2,6-piperidinedione hydrochloride, diisopropylethylamine, hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N,N-dimethylformamide; (iv) chlorotrimethylsilane, triethylamine, acetonitrile, 75 °C and then deuterium oxide, room temperature; and (v) H2, Pd(OH)2, N,N-dimethylformamide.
