Fig. 2.

Transcript expression of downstream molecules regulated by Nrf2 is significantly higher in naked mole-rats than in mice. Naked mole-rats have higher levels of several gene transcripts that are dominantly regulated by Nrf2 (n = 5 or 6). (A) These include Hmox1 (Left; P = 0.0376), Gsta1 (Center; P = 0.0336), and Nqo1 (Right; P = 0.0200). (B and C) Elevated Nrf2-signaling activity in the naked mole-rat was further confirmed via higher total GST (B; P = 0.0001) and NQO1 activities (C; P = 0.0002) than observed in mice. Error bars represent SEM.