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Proteins identified by chromatin proteomic profiling that are associated with human diseases. (A) Distribution of proteins (blue or red nodes) that were enriched in each histone mark ChIP-MS preparation (green nodes) relative to the IgG control and input samples. Red nodes represent proteins associated with diseases. (B and C) The number and relative enrichment of chromatin-associated proteins identified in this study that are mutated in cancers (B) and Mendelian diseases (C).
