Fig. 6.

Recognition model of the kinase for ${\text{PLN}}_{1-19}^{WT}$ and ${\text{PLN}}_{1-19}^{R14del}$. On nucleotide binding, the enzyme’s conformational ensemble shifts toward the intermediate conformation and with dynamics committed to catalysis. With${\text{PLN}}_{1-19}^{WT}$, the two arginine residues of the PKA-C recognition sequence clamp together both lobes of the enzyme to produce a catalytically committed complex, whereas the PKA-C/${\text{PLN}}_{1-19}^{R14del}$ complex adopts a partially closed conformation with dysfunctional dynamics.