Figure 9.
NAD+-dependent regulation of PARP-1 and PARP-1–SIRT1 crosstalk. (A) NMNAT-1 regulates PARP-1 or SIRT1-dependent transcription. (B) Competition between PARP-1 and SIRT1 for the common substrate NAD+. (C) Deacetylation of PARP-1 by SIRT1.
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